Recent studies have revealed that tetrahydrocannabinol (THC), the active compound in cannabis, could be an effective remedy for combating brain aging symptoms in rats. This discovery may pave the way for new strategies aimed at preserving cognitive function and mental sharpness as we age.Groundbreaking research from Germany and IsraelResearchers from Germany and Israel conducted the study, building on previous research related to the endocannabinoid system and cannabinoid receptor type-1 (CB1). Their findings indicate that THCs anti-aging properties work through a signaling pathway involving the mTOR protein, which plays a crucial role in cell metabolism and the metabolome.A press release from the University of Bonn, Germany, highlighted that in an earlier study, researchers from Bonn, in collaboration with a team from the Hebrew University of Jerusalem, demonstrated that long-term, low-dose THC administration could have anti-aging effects on the brain. This was evidenced by restored cognitive abilities and increased synapse density in aged mice. However, the connection between changes in mTOR signaling and the metabolome and their impact on the aging brain remained unclear.THCs dual effect on brain and bodyDr. Andras Bilkei-Gorzo, from the Institute of Molecular Psychiatry at the University of Bonn, explained, We have now been able to show that treatment with THC has a tissue-dependent and dual effect on mTOR signaling and the metabolome. The study revealed that THC treatment in the brain led to a temporary increase in mTOR activity and the levels of intermediates involved in energy production and amino acids. This, in turn, promoted the synthesis of synaptic proteins and the formation of new synapses.Interestingly, the researchers also observed a significant reduction in mTOR activity in the adipose tissue of mice, along with decreased levels of amino acids and carbohydrate metabolites in blood plasma, similar to the effects of a low-calorie diet or intensive physical activity.Dr. Bilkei-Gorzo concluded, Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective anti-aging and cognition-enhancing drug.
