Matthew Perry's death: Autopsy reveals ketamine presence

The untimely death of Friends actor Matthew Perry has been attributed to the "acute effects of ketamine," as disclosed in the recently released autopsy report. However, the circumstances surrounding the origin and purpose of Perry's ketamine use remain shrouded in mystery. Dr Bankole Johnson, a distinguished neuroscientist, suggests the possibility of illicit acquisition for "recreational" purposes.

Dr Johnson, in an interview with Page Six, voiced concerns about the dangers of combining ketamine with buprenorphine, a medication Perry was taking for opioid addiction. Describing it as a "recipe for disaster," he emphasised the likelihood of Perry's ketamine use being recreational rather than therapeutic.

Matthew Perry died of acute effects of Ketamine, autopsy reveals

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Ketamine Infusion Therapy vs. Recreational Use

Contrary to recreational use claims, Perry had documented ketamine infusion therapy for depression and anxiety just a week and a half before his demise. Dr Johnson underscores the importance of professional administration, advocating for IV drip methods to ensure precise dosage control. He warns against intranasal self-administration, citing safety concerns and increased drug-seeking behaviour.

"Intranasal use is generally less safe as it is often self-administered. This also can drive drug-seeking more aggressively," says Dr Johnson.

Friends' Perspective and Toxicology Findings

Contrary to any visible signs of distress, Perry's friend and 'Friends' co-star, Jennifer Aniston, conveyed that he appeared happy and content before his death. Toxicology findings, however, revealed elevated ketamine levels in Perry's system, surpassing typical ranges for controlled medical settings.

Buprenorphine's Influence and Medical Examiner's Report

The complexity of Perry's case is heightened by the involvement of buprenorphine, known to enhance ketamine's sedative effects. Dr Johnson describes this interaction as catalytic, potentially leading to unresponsiveness. The Los Angeles County Medical Examiner's report acknowledges ketamine's misuse in recreational settings but refrains from conclusively stating whether Perry's use was illegal or not.